Project publications

Pagano S, Carbone F, Burger F, Roth A, Bertolotto M, Pane B, Spinella G, Palombo D, Pende A, Dallegri F, Satta N, Virzi J, Fontana P, Mach F, Montecucco F, Vuilleumier N. Anti-Apolipoprotein A-1 autoantibodies as active modulators of atherothrombosis. Thromb Haemost. In press 2016.

Montecucco F, Bondarenko AI, Lenglet S, Burger F, Piscitelli F, Carbone F, Roth A, Liberale L, Dallegri F, Brandt KJ, Fraga-Silva RA, Stergiopulos N, Di Marzo V, Mach F. Treatment with the GPR55 antagonist CID16020046 increases neutrophil activation in mouse atherogenesis. Thromb Haemost. In press 2016.

Carbone F, Satta N, Montecucco F, Virzi J, Burger F, Roth A, Roversi G, Tamborino C, Casetta I, Seraceni S, Trentini A, Padroni M, Dallegri F, Lalive PH, Mach F, Fainardi E, Vuilleumier N. Anti-ApoA-1 IgG serum levels predict worse post-stroke outcomes. Eur J Clin Invest. In press 2016.

Carbone F, Bonaventura A, Liberale L, Cea M, Montecucco F. Targeting inflammation in primary cardiovascular prevention. Curr Pharm Des. In press 2016.

Liberale L, Bonaventura A, Dallegri F, Montecucco F, Carbone F. Impact of red wine consumption on cardiovascular health. Curr Med Chem. In press 2016.

Strom AC, Cross AJ, Cole JE, Blair PA, Leib C, Goddard ME, Rosser EC, Park I, Hultgårdh Nilsson A, Nilsson J, Mauri C, Monaco C. B regulatory cells are increased in hypercholesterolaemic mice and protect from lesion development via IL-10. Thromb Haemost. 2015 Oct;114(4):835-47. doi: 10.1160/TH14-12-1084. Epub 2015 Jun 11.

Cole JE, Astola N, Cribbs AP, Goddard ME, Park I, Green P, Davies AH, Williams RO, Feldmann M, Monaco C. Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13033-8. doi: 10.1073/pnas.1517820112.

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Bornschein J, Nielitz J, Drozdov I, Selgrad M, Wex T, Jechorek D, Link A, Vieth M, Malfertheiner P. Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer. Cancer Med. 2016 Mar;5(3):516-26. doi: 10.1002/cam4.610. Epub 2016 Jan 18.

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Centa M, Gruber S, Nilsson D, Polyzos KA, Johansson DK, Hansson GK, Ketelhuth DF, Binder CJ, Malin S. Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene. Arterioscler Thromb Vasc Biol. 2016 Jan; 36(1) : 25-36. doi: 10.1161/ATVBAHA.115.305990. Epub 2015 Nov 12.

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Björkbacka H, Alm R, Persson M, Hedblad B, Nilsson J, Fredrikson GN. Low Levels of Apolipoprotein B-100 Autoantibodies Are Associated With Increased Risk of Coronary Events. Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):765-71. doi: 10.1161/ATVBAHA.115.306938. Epub 2016 Feb 25.

Carbone F, Burger F, Roversi G, Tamborino C, Casetta I, Seraceni D, Trentini A, Padroni M, Bertolotto M, Dallegri F, Mach F, Fainardi E, Montecucco F. Leptin/adiponectin ratio predicts post-stroke neurological outcome. Eur J Clin Invest. 2015 Nov;45(11):1184-91. doi: 10.1111/eci.12538. Epub 2015 Oct 19.

Montecucco F, Lenglet S, Carbone F, Boero S, Pelli G, Burger F, Roth A, Bertolotto M, Nencioni A, Cea M, Dallegri F, Fraga-Silva RA, Fougère L, Elfakir C, Gassner AL, Rudaz S, Parissaux X, Wils D, Salomé M, Vuilleumier N, Poggi A, Mach F. Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response. Vascul Pharmacol. 2015 Sep;72:197-208. doi: 10.1016/j.vph.2015.04.008. Epub 2015 Apr 25.

Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Cea M, Monacelli F, Odetti P, Ballestrero A, Uccelli A, Mostoslavsky R, Poggi A, Nencioni A. Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY). 2016 Jan;8(1):34-49.

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Carbone F, Crowe LA, Roth A, Burger F, Lenglet S, Braunersreuther V, Brandt KJ, Quercioli A, Mach F, Vallée JP, Montecucco F. Treatment with anti-RANKL antibody reduces infarct size and attenuates dysfunction impacting on neutrophil-mediated injury. J Mol Cell Cardiol. 2016 May; 94:82-94. doi: 10.1016/j.yjmcc.2016.03.013. Epub 2016 Apr 5.

Pende A, Artom N, Bertolotto M, Montecucco F, Dallegri F. Role of Neutrophils in Atherogenesis: an Update. Eur J Clin Invest. 2016 Mar;46(3):252-63. doi: 10.1111/eci.12566. Epub 2016 Feb 2. Review.

Gomes Quinderé AL, Barros Benevides NM, Pelli G, Lenglet S, Burger F, Carbone F, Fraga-Silva RA, Stergiopulos N, Pagano S, Bertolotto M, Dallegri F, Vuilleumier N, Mach F, Montecucco F. Treatment with sulphated galactan inhibits macrophage chemotaxis and reduces intraplaque macrophage content in atherosclerotic mice. Vascul Pharmacol. 2015 Aug;71:84-92. doi: 10.1016/j.vph.2015.02.015. Epub 2015 Apr 10.

Montecucco F, Braunersreuther V, Burger F, Lenglet S, Pelli G, Carbone F, Fraga-Silva RA, Stergiopulos N, Monaco C, Mueller C, Pagano S, Dallegri F, Mach F, Vuilleumier N. Anti-apoA-1 auto-antibodies increase mouse atherosclerotic plaque vulnerability, myocardial necrosis and mortality triggering TLR2 and TLR4. Thromb Haemost. 2015 Aug;114(2):410-22. doi: 10.1160/TH14-12-1039. Epub 2015 Apr 16.

Rubini Gimenez M, Pagano S, Virzi J, Montecucco F, Twerenbold R, Reichlin T, Wildi K, Grueter D, Jaeger C, Haaf P, Vuilleumier N, Mueller C. Diagnostic and prognostic value of autoantibodies anti-apolipoprotein A-1 and anti-phosphorylcholine in acute non-ST elevation myocardial infarction. Eur J Clin Invest. 2015 Apr;45(4):369-79. doi: 10.1111/eci.12411. Epub 2015 Mar 9.

Montecucco F, Lenglet S, Quercioli A, Burger F, Thomas A, Lauer E, da Silva AR, Mach F, Vuilleumier N, Bobbioni-Harsch E, Golay A, Schindler TH, Pataky Z. Gastric bypass in morbid obese patients is associated with reduction in adipose tissue inflammation via N-oleoylethanolamide (OEA)-mediated pathways. Thromb Haemost. 2015 Apr;113(4):838-50. doi: 10.1160/TH14-06-0506. Epub 2014 Nov 20.

Akhmedov A, Montecucco F, Braunersreuther V, Camici GG, Jacob P, Reiner MF, Glanzmann M, Burger F, Paneni F, Galan K, Pelli G, Vuilleumier N, Belin A, Vallée JP, Mach F, Lüscher TF. Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischemic myocardial injury via intracellular salvage pathways. Eur Heart J. 2015 Feb 21;36(8):516-26a. doi: 10.1093/eurheartj/ehu400. Epub 2014 Oct 21.

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Carbone F, Mach F, Montecucco F. The role of adipocytokines in atherogenesis and atheroprogression. Curr Drug Targets. 2015;16(4):295-320. Review.

Carbone F, Mach F, Montecucco F. Update on the role of neutrophils in atherosclerotic plaque vulnerability. Curr Drug Targets. 2015;16(4):321-33. Review.

Carbone F, Teixeira PC, Braunersreuther V, Mach F, Vuilleumier N, Montecucco F. Pathophysiology and treatments of oxidative injury in ischemic stroke: focus on the phagocytic NADPH oxidase (NOX) 2. Antioxid Redox Signal. 2015 Aug 10;23(5):460-89. doi: 10.1089/ars.2013.5778. Epub 2014 Apr 22. Review.

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Carbone F, Bovio M, Rosa GM, Ferrando F, Scarrone A, Murialdo G, Quercioli A, Vuilleumier N, Mach F, Viazzi F, Montecucco F. Inferior vena cava parameters predict readmission in ischemic heart failure. Eur J Clin Invest. 2014;44:341-9. doi: 10.1111/eci.12238. Epub 2014 Feb 8.

Carbone F, Mach F, Vuilleumier N, Montecucco F. Cannabinoid receptor type 2 activation in atherosclerosis and acute cardiovascular diseases. Curr Med Chem. 2014;21:4046-58.

Carbone F, Mach F, Vuilleumier N, Montecucco F. Potential pathophysiological role for the vitamin D deficiency in essential hypertension. World J Cardiol. 2014;6:260-276. doi: 10.4330/wjc.v6.i5.260. Review.

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Rosa GM, Carbone F, Parodi A, Massimelli EA, Brunelli C, Mach F, Vuilleumier N, Montecucco F. Update on the efficacy of statin treatment in Acute Coronary Syndromes. Eur J Clin Invest. 2014;44:501-15. doi: 10.1111/eci.12255. Review.

Sanguineti R, Puddu A, Mach F, Montecucco F, Viviani GL. Advanced Glycation End-Products (AGEs) play adverse pro-inflammatory activities in osteoporosis. Mediators Inflamm. 2014;2014:975872. doi: 10.1155/2014/975872. Epub 2014 Mar 20. Review.

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Quinderé AL, Barros Benevides NM, Carbone F, Mach F, Vuilleumier N, Montecucco F. Update on selective treatments targeting neutrophilic inflammation in atherogenesis and atherothrombosis. Thromb Haemost. 2014;111:634-46. doi: 10.1160/TH13-08-0712. Epub 2013 Nov 28. Review.

Artom N, Montecucco F, Mach F, Dallegri F, Pende A. Angiotensin II Receptor Antagonists in Acute Coronary Syndromes. Eur J Clin Invest. 2014;44:219-230. doi: 10.1111/eci.12198. Epub 2013 Dec 2.

Montecucco F, Mach F, Lenglet S, Vonlaufen A, Gomes Quinderé AL, Pelli G, Burger F, Galan K, Dallegri F, Carbone F, Proudfoot AE, Vuilleumier N, Frossard JL. Treatment with Evasin-3 abrogates neutrophil-mediated inflammation in mouse acute pancreatitis. Eur J Clin Invest. 2014;44:940-50. doi: 10.1111/eci.12327.

Lenglet S, Montecucco F, Mach F, Schaller K, Gasche Y, Copin JC. Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischemic stroke. Thromb Haemost. 2014;112:363-78. doi: 10.1160/TH14-01-0007. Epub 2014 Mar 27.

Lenglet S, Montecucco F, Denes A, Coutts G, Pinteaux E, Mach F, Schaller K, Gasche Y, Copin JC. Recombinant tissue plasminogen activator enhances microglial cell recruitment after stroke in mice. J Cereb Blood Flow Metab. 2014;34:802-12. doi: 10.1038/jcbfm.2014.9. Epub 2014 Jan 29.