Targeting and exploiting B cell functions for treatment in
Objective 1: To define targets to reduce activation of pathogenic B cells and antibodies in Cardiovascular Diseases.
Objective 2: To identify enhancers of atheroprotective B regulatory cell populations and antibodies in Cardiovascular Diseases.
Objective 3: To validate molecular and miRNA targets to modulate B cell behavior in Cardiovascular Diseases with innovative locked nucleic
acid (LNA) based antisense platforms.